The continuum of antibody epitopes on the GP waist viewed from the top (left) and side (right).  Site A includes the conserved hydrophobic pocket beneath the GP2 tail recognized by Adi-15878. Antibodies interacting with epitopes in Sites A-C are more likely to cross-reactive.  Only one naturally occurring human antibody, ADI-15878, is currently known that can … Continued

Single particle negative stain electron microscopy of 6D6 Fab fragment bound to EBOV GP (side view, left and top view, right). The GP and Fab are shown in grey and blue, respectively with the crystal structures shown as ribbon diagrams for reference. The 2014-2016 Ebola virus disease (EVD) outbreak in West Africa caused by Ebola … Continued