What lies beneath: Structural features that confer pan-ebolavirus activity

The continuum of antibody epitopes on the GP waist viewed from the top (left) and side (right).  Site A includes the conserved hydrophobic pocket beneath the GP2 tail recognized by Adi-15878. Antibodies interacting with epitopes in Sites A-C are more likely to cross-reactive.  Only one naturally occurring human antibody, ADI-15878, is currently known that can … Continued