The continuum of antibody epitopes on the GP waist viewed from the top (left) and side (right).  Site A includes the conserved hydrophobic pocket beneath the GP2 tail recognized by Adi-15878. Antibodies interacting with epitopes in Sites A-C are more likely to cross-reactive.  Only one naturally occurring human antibody, ADI-15878, is currently known that can … Continued

Single particle negative stain electron microscopy of 6D6 Fab fragment bound to EBOV GP (side view, left and top view, right). The GP and Fab are shown in grey and blue, respectively with the crystal structures shown as ribbon diagrams for reference. The 2014-2016 Ebola virus disease (EVD) outbreak in West Africa caused by Ebola … Continued

Antibodies targeting the Ebola virus glycoprotein that lack neutralization activity can nonetheless offer protection by promoting activation of natural killer (NK) cells and monocyte phagocytosis.  (from Gunn et al. Cell Host Microbe https://doi.org/10.1016/j.chom.2018.07.009) In a companion publication to the Saphire et al.Cell manuscript published online in Cell Host Microbe on August 7, 2018 Gunn et … Continued

VIC researchers analyzed features for each of 171 monoclonal antibodies in the VIC panel to define correlations between antibody characteristics and ability to offer protection (Graphical abstract from Saphire et al. doi: 10.1016/j.cell.2018.07.033)   In their paper published online on August 9, 2018 in Cell the VIC describes findings from a multi-year study conducted on … Continued