Research in the Garry Laboratory focuses on a number of aspects of viral pathogenesis. He was involved in collaborative studies that lead to the determination that entry proteins of enveloped viruses form at least three distinct structural classes. Dr. Garry continues to maintain a broad interest in the mechanisms of enveloped virus entry. He has a long-standing interest in viral diagnostics dating back to his work with the industry scientists who developed the first generation of ELISA and western blot assays to detect serum antibodies to HIV-1. These early studies on viral diagnostics lead to his characterization of an isolate of HIV from a patient who died of AIDS in 1969, the earliest confirmed case of AIDS in the United States.